Welcome to the
Karantanos Lab
About Us
The focus of the Karantanos lab is the dissection of the molecular biology of progression of acute leukemias with erythroid differentiation and acute leukemias arising from antecedent myeloproliferative neoplasms. Specifically, we investigate the regulation of JAK2/STAT pathway and the implication of inflammatory signaling in these diseases incorporating single cell analysis, CRISPR-Cas9 screens, signal transduction studies and erythroid leukemia xenograft mouse models. Our ultimate goal is to identify novel targeted therapies that can improve the outcomes of patients with these lethal subtypes of acute myeloid leukemia.
Our Research
Our studies focus on understanding the molecular biology of the progression of acute leukemias with erythroid differentiation and leukemias arising from antecedent myeloproliferative neoplasms. Particularly, we are interested in dissecting the regulation of JAK2/STAT pathway and the implication of STAT-regulated inflammatory pathways in the progression of these diseases and the development of resistance to current therapies such as chemotherapy and JAK2 inhibitors. We also study the activity of targeted therapies such RAS inhibitors in acute leukemias arising from antecedent myeloid neoplasms.
News & Updates
Hematologic Malignancies/Bone Marrow Transplantation Pilot Grant
Karantanos lab wins one of the two Hematologic Malignancies/Bone Marrow Transplantation pilot grants
Nour Naji’s poster recognized
Nour Naji’s poster is recognized as one of the top 10 abstracts in Hopkins Research Retreat!
Let's Work Together!
The Karantanos Lab is interested in collaborating. Drop us a line.