The focus of the Karantanos lab is the dissection of the molecular biology of progression of acute leukemias with erythroid differentiation and acute leukemias arising from antecedent myeloproliferative neoplasms. Specifically, we investigate the regulation of JAK2/STAT pathway and the implication of inflammatory signaling in these diseases incorporating single cell analysis, CRISPR-Cas9 screens, signal transduction studies and erythroid leukemia xenograft mouse models. Our ultimate goal is to identify novel targeted therapies that can improve the outcomes of patients with these lethal subtypes of acute myeloid leukemia.